A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF
Joint Authors
Sutcu, Havva
Akpak, Yaşam Kemal
Turgay Çelik, Gayem İnayet
Akar, Münire Erman
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to in vitro fertilization (IVF).
Study Design.
A retrospective study in Akdeniz University, Faculty of Medicine, Department of Obstetrics and Gynecology, IVF Center, for 131 poor responders in the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) program between January 2006 and November 2012.
The groups were compared to the patients’ characteristics, controlled ovarian stimulation (COH) results, and laboratory results.
Results.
Combination protocol was applied to 46 patients (group 1), and a single protocol was applied to 85 patients (group 2).
In group 1, the duration of the treatment was longer and the dose of FSH was higher.
The cycle cancellation rate was significantly higher in group 2 (26.1% versus 38.8%).
A significant difference was not observed with respect to the number and quality of oocytes and embryos or to the number of embryos transferred.
There were no statistically significant differences in the hCG positivity (9.5% versus 9.4%) or the clinical pregnancy rates (7.1% versus 10.6%).
Conclusion.
The combination protocol does not provide additional efficacy.
American Psychological Association (APA)
Turgay Çelik, Gayem İnayet& Sutcu, Havva& Akpak, Yaşam Kemal& Akar, Münire Erman. 2015. A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057432
Modern Language Association (MLA)
Turgay Çelik, Gayem İnayet…[et al.]. A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057432
American Medical Association (AMA)
Turgay Çelik, Gayem İnayet& Sutcu, Havva& Akpak, Yaşam Kemal& Akar, Münire Erman. A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057432