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Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture
Joint Authors
Wuest, Simon L.
Richard, Stéphane
Kopp, Sascha
Egli, Marcel
Grimm, Daniela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Random Positioning Machines (RPMs) have been used since many years as a ground-based model to simulate microgravity.
In this review we discuss several aspects of the RPM.
Recent technological development has expanded the operative range of the RPM substantially.
New possibilities of live cell imaging and partial gravity simulations, for example, are of particular interest.
For obtaining valuable and reliable results from RPM experiments, the appropriate use of the RPM is of utmost importance.
The simulation of microgravity requires that the RPM’s rotation is faster than the biological process under study, but not so fast that undesired side effects appear.
It remains a legitimate question, however, whether the RPM can accurately and reliably simulate microgravity conditions comparable to real microgravity in space.
We attempt to answer this question by mathematically analyzing the forces working on the samples while they are mounted on the operating RPM and by comparing data obtained under real microgravity in space and simulated microgravity on the RPM.
In conclusion and after taking the mentioned constraints into consideration, we are convinced that simulated microgravity experiments on the RPM are a valid alternative for conducting examinations on the influence of the force of gravity in a fast and straightforward approach.
American Psychological Association (APA)
Wuest, Simon L.& Richard, Stéphane& Kopp, Sascha& Grimm, Daniela& Egli, Marcel. 2015. Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057437
Modern Language Association (MLA)
Wuest, Simon L.…[et al.]. Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057437
American Medical Association (AMA)
Wuest, Simon L.& Richard, Stéphane& Kopp, Sascha& Grimm, Daniela& Egli, Marcel. Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057437