Associations of C1qTNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans

Joint Authors

Wang, Jing
Hang, Tao
Cheng, Xun-min
Li, De-min
Zhang, Qi-gao
Wang, Li-jun
Peng, Yong-ping
Gong, Jian-bin

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-09-17

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Objective.

To investigate the correlation of CTRP9 with coronary atherosclerosis.

Methods.

Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).

Results.

Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients ( P < 0.05 ), but APN and CTRP9 were lower ( P < 0.05 ).

Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C ( P < 0.05 ) in CAD patients.

After adjustment of APN, CTRP9 was still related to the above parameters.

Serum CTRP9 was a protective factor of CAD ( P < 0.05 ).

When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients ( P < 0.05 ).

The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression ( P < 0.05 ).

Conclusions.

Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients.

Serum CTRP9 is an independent protective factor of CAD.

American Psychological Association (APA)

Wang, Jing& Hang, Tao& Cheng, Xun-min& Li, De-min& Zhang, Qi-gao& Wang, Li-jun…[et al.]. 2015. Associations of C1qTNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057438

Modern Language Association (MLA)

Wang, Jing…[et al.]. Associations of C1qTNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057438

American Medical Association (AMA)

Wang, Jing& Hang, Tao& Cheng, Xun-min& Li, De-min& Zhang, Qi-gao& Wang, Li-jun…[et al.]. Associations of C1qTNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057438

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1057438