Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport
Joint Authors
Satoh, Nobuhiko
Horita, Shoko
Suzuki, Atsushi
Nakamura, Motonobu
Seki, George
Suzuki, Masashi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A serine/threonine kinase Akt is a key mediator in various signaling pathways including regulation of renal tubular transport.
In proximal tubules, Akt mediates insulin signaling via insulin receptor substrate 2 (IRS2) and stimulates sodium-bicarbonate cotransporter (NBCe1), resulting in increased sodium reabsorption.
In insulin resistance, the IRS2 in kidney cortex is exceptionally preserved and may mediate the stimulatory effect of insulin on NBCe1 to cause hypertension in diabetes via sodium retention.
Likewise, in distal convoluted tubules and cortical collecting ducts, insulin-induced Akt phosphorylation mediates several hormonal signals to enhance sodium-chloride cotransporter (NCC) and epithelial sodium channel (ENaC) activities, resulting in increased sodium reabsorption.
Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates aldosterone signaling.
Insulin can stimulate SGK1 to exert various effects on renal transporters.
In renal cortical collecting ducts, SGK1 regulates the expression level of ENaC through inhibition of its degradation.
In addition, SGK1 and Akt cooperatively regulate potassium secretion by renal outer medullary potassium channel (ROMK).
Moreover, sodium-proton exchanger 3 (NHE3) in proximal tubules is possibly activated by SGK1.
This review focuses on recent advances in understanding of the roles of Akt and SGK1 in the regulation of renal tubular transport.
American Psychological Association (APA)
Satoh, Nobuhiko& Nakamura, Motonobu& Suzuki, Masashi& Suzuki, Atsushi& Seki, George& Horita, Shoko. 2015. Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057439
Modern Language Association (MLA)
Satoh, Nobuhiko…[et al.]. Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057439
American Medical Association (AMA)
Satoh, Nobuhiko& Nakamura, Motonobu& Suzuki, Masashi& Suzuki, Atsushi& Seki, George& Horita, Shoko. Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057439