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Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin
Joint Authors
Bonanni, Bernardo
Cazzaniga, Massimiliano
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells.
It has long been believed that the increase of metabolic request was independent of the mitochondrial action but recently we know that mitochondrial activity together with metabolism plays a pivotal role in the regulation of the energy needed for tumor cell growth and proliferation.
For these reasons the mitochondria pathways could be a new target for therapeutic and chemopreventive intervention.
Metformin in particular is actually considered a promising agent against mitochondrial activity thanks to its ability to inhibit the mitochondrial complex I.
American Psychological Association (APA)
Cazzaniga, Massimiliano& Bonanni, Bernardo. 2015. Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057441
Modern Language Association (MLA)
Cazzaniga, Massimiliano& Bonanni, Bernardo. Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057441
American Medical Association (AMA)
Cazzaniga, Massimiliano& Bonanni, Bernardo. Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057441