Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment
Joint Authors
He, Ningning
Liu, Chen
Wang, Lina
Tong, Lingling
Chen, Yanan
Liu, Yanhua
Wu, Zhongjun
Sun, Peiqing
Xiang, Rong
Ren, Guosheng
Su, Weijun
Li, Zongjin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Angiogenesis plays an important role in the progression of tumor.
Besides being regulated by tumor cells per se, tumor angiogenesis is also influenced by stromal cells in tumor microenvironment (TME), for example, tumor associated macrophages (TAMs).
Activating transcription factor 4 (ATF4), a member of the ATF/CREB family, has been reported to be related to tumor angiogenesis.
In this study, we found that exogenous overexpression of ATF4 in mouse breast cancer cells promotes tumor growth via increasing tumor microvascular density.
However, ATF4 overexpression failed to increase the expression level of a series of proangiogenic factors including vascular endothelial growth factor A (VEGFA) in tumor cells in this model.
Thus, we further investigated the infiltration of proangiogenic macrophages in tumor tissues and found that ATF4-overexpressing tumors could recruit more macrophages via secretion of macrophage colony stimulating factor (M-CSF).
Overall, we concluded that exogenous overexpression of ATF4 in breast cancer cells may facilitate the recruitment of macrophages into tumor tissues and promote tumor angiogenesis and tumor growth indirectly.
American Psychological Association (APA)
Liu, Chen& Li, Zongjin& Wang, Lina& Tong, Lingling& He, Ningning& Chen, Yanan…[et al.]. 2015. Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057453
Modern Language Association (MLA)
Liu, Chen…[et al.]. Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057453
American Medical Association (AMA)
Liu, Chen& Li, Zongjin& Wang, Lina& Tong, Lingling& He, Ningning& Chen, Yanan…[et al.]. Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057453