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Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency
Joint Authors
Zaikin, Alexey
Druzhkov, Pavel
Zolotykh, Nikolay
Meyerov, Iosif
Shutova, Maria
Ivanchenko, Mikhail
Alsaedi, Ahmed
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures.
The resulting average accuracy of classification has been proven to be above 95%, which overcomes the earlier achievements.
We propose a constructive and transparent method of feature selection based on classifier accuracy.
Enrichment analysis reveals statistically meaningful presence of stemness group and cancer discriminating genes among the selected best classifying features.
These findings stimulate the further research on the functional consequences of these differences in methylation patterns.
The presented approach can be broadly used to discriminate the cells of different phenotype or in different state by their methylation profiles, identify groups of genes constituting multifeature classifiers, and assess enrichment of these groups by the sets of genes with a functionality of interest.
American Psychological Association (APA)
Druzhkov, Pavel& Zolotykh, Nikolay& Meyerov, Iosif& Alsaedi, Ahmed& Shutova, Maria& Ivanchenko, Mikhail…[et al.]. 2015. Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057463
Modern Language Association (MLA)
Druzhkov, Pavel…[et al.]. Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057463
American Medical Association (AMA)
Druzhkov, Pavel& Zolotykh, Nikolay& Meyerov, Iosif& Alsaedi, Ahmed& Shutova, Maria& Ivanchenko, Mikhail…[et al.]. Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057463