MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far
Joint Authors
Fernandes, Alexandra R.
Raposo, Luís R.
Roma-Rodrigues, Catarina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by variable expressivity, age penetrance, and a high heterogeneity.
The transcriptional profile (miRNAs, mRNAs), epigenetic modifications, and posttranslational modifications seem to be highly relevant for the onset of the disease.
miRNAs, small noncoding RNAs with 22 nucleotides, have been implicated in the regulation of cardiomyocyte function, being differentially expressed in several heart diseases, including HCM.
Moreover, a different miRNA expression profile in the various stages of HCM development is also observed.
This review summarizes the current knowledge of the profile of miRNAs characteristic of asymptomatic to overt HCM patients, discussing alongside their potential use for diagnosis and therapy.
Indeed, the stability and specificity of miRNAs make them suitable targets for use as biomarkers for diagnosis and prognosis and as therapeutical targets.
American Psychological Association (APA)
Roma-Rodrigues, Catarina& Raposo, Luís R.& Fernandes, Alexandra R.. 2015. MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057481
Modern Language Association (MLA)
Roma-Rodrigues, Catarina…[et al.]. MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057481
American Medical Association (AMA)
Roma-Rodrigues, Catarina& Raposo, Luís R.& Fernandes, Alexandra R.. MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057481