The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases
Joint Authors
Li, Chong-Hui
Chen, Jie
Chen, Liangan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Microvesicles (MVs) are membrane vesicles that are released by many types of cells and have recently been considered important mediators of cell-to-cell communication.
MVs serve as a vehicle to transfer proteins and messenger RNA and microRNA (miRNA) to distant cells, which alters the gene expression, proliferation, and differentiation of the recipient cells.
Several studies have demonstrated that mesenchymal stem cells (MSCs) have the capacity to reverse acute and chronic lung injury in different experimental models through paracrine mechanisms.
This paracrine action may be partially accounted for by MVs that are derived from MSCs.
MSC-derived MVs may confer a stem cell-like phenotype to injured cells with the consequent activation of self-regenerative programmers.
In this review, we summarize the characteristics and biological activities of MSC-derived MVs, and we describe their potential in novel therapeutic approaches in regenerative medicine to repair damaged tissues.
Additionally, we provide an overview of studies that have assessed the role of MSC-derived MVs in lung diseases, including the mechanisms that may account for their therapeutic potential.
Finally, we discuss the clinical use of MSC-derived MVs with several suggestions for enhancing their therapeutic efficiency.
American Psychological Association (APA)
Chen, Jie& Li, Chong-Hui& Chen, Liangan. 2015. The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057489
Modern Language Association (MLA)
Chen, Jie…[et al.]. The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057489
American Medical Association (AMA)
Chen, Jie& Li, Chong-Hui& Chen, Liangan. The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057489