![](/images/graphics-bg.png)
Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes
Joint Authors
De Falco, Giulia
Ambrosio, Maria Raffaella
Ginori, Alessandro
Rocca, Bruno J.
Barone, Aurora
Crivelli, Filippo
Calandra, Calogera
Gazaneo, Sara
Tripodi, Sergio
Cevenini, Gabriele
del Vecchio, Maria Teresa
Tosi, Piero
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Prostate cancer is the second leading cause of cancer-related death.
The androgen deprivation therapy is the standard treatment for advanced stages.
Unfortunately, virtually all tumors become resistant to androgen withdrawal.
The progression to castration-resistance is not fully understood, although a recent paper has suggested translationally controlled tumor protein to be implicated in the process.
The present study was designed to investigate the role of this protein in prostate cancer, focusing on the correlation between its expression level with tumor differentiation and response to treatment.
We retrieved 292 prostatic cancer specimens; of these 153 had been treated only by radical prostatectomy and 139 had undergone radical prostatectomy after neoadjuvant treatment with combined androgen blockade therapy.
Non-neoplastic controls were represented by 102 prostatic peripheral zone specimens.
In untreated patients, the expression of the protein, evaluated by RT-qPCR and immunohistochemistry, was significantly higher in tumor specimens than in non-neoplastic control, increasing as Gleason pattern and score progressed.
In treated prostates, the staining was correlated with the response to treatment.
An association between protein expression and the main clinicopathological factors involved in prostate cancer aggressiveness was identified.
These findings suggest that the protein may be a promising prognostic factor and a target for therapy.
American Psychological Association (APA)
Rocca, Bruno J.& Ginori, Alessandro& Barone, Aurora& Calandra, Calogera& Crivelli, Filippo& De Falco, Giulia…[et al.]. 2015. Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057490
Modern Language Association (MLA)
Rocca, Bruno J.…[et al.]. Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057490
American Medical Association (AMA)
Rocca, Bruno J.& Ginori, Alessandro& Barone, Aurora& Calandra, Calogera& Crivelli, Filippo& De Falco, Giulia…[et al.]. Translationally Controlled Tumor Protein in Prostatic Adenocarcinoma: Correlation with Tumor Grading and Treatment-Related Changes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057490