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A Redox-Sensitive Micelle-Like Nanoparticle Self-Assembled from Amphiphilic Adriamycin-Human Serum Albumin Conjugates for Tumor Targeted Therapy
Joint Authors
Li, Wei
Zhao, Mengxin
Ke, Changhong
Zhang, Fulei
Sun, Yun
Chen, Lin
Chen, Feng
Zhu, Xiandi
Yu, Jiangming
Yan, Zhiqiang
Chen, Di
Jiang, Cheng
Gao, Yong
Guo, Shangjing
Zhao, Xian-Xian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited byits side effects like high toxicity and insolubility.
Nanomedicine offers new hope forovercoming the shortcomings.
But how to increase in vivo stability and to control intracellulardrug release is a key issue for nano-based formulations.
Herein, the hydrophobic ADR wassuccessfully linked to the biocompatible human serum albumin (HSA) by disulfide bond3-(2-pyridyldithio) propionyl hydrazide (PDPH), resulting in amphiphilic HSA-ADR.
Thenovel ADR-HSA micellar NPs which were thus assembled exhibited a well-defined stablecore shell structure with glutathione (GSH) sensitive linkers.
The stable PDPH linkers atextracellular level were broken by GSH at intracellular level with a controlled ADR releaseprofile.
The in vitro cytotoxicity against gastric cancer cells (NCI-N87) was obviouslyenhanced by such redox-sensitive ADR-HSA NPs.
Additionally, as observed by IVISLumina II Imaging System (Xenogen), the intratumor accumulation of ADR-HSA NPs wasmuch higher than that of HSA/ADR NPs due to its high stability.
Consequently, the in vivotumor inhibition was significantly promoted after intravenous administration to the Balb/c nude micebearing gastric tumors.
These in vitro/vivo results indicated that disulfide-bond-containingADR-HSA NPs were an effective nanodrug delivery system for cancer therapy.
American Psychological Association (APA)
Chen, Lin& Chen, Feng& Zhao, Mengxin& Zhu, Xiandi& Ke, Changhong& Yu, Jiangming…[et al.]. 2015. A Redox-Sensitive Micelle-Like Nanoparticle Self-Assembled from Amphiphilic Adriamycin-Human Serum Albumin Conjugates for Tumor Targeted Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057499
Modern Language Association (MLA)
Chen, Lin…[et al.]. A Redox-Sensitive Micelle-Like Nanoparticle Self-Assembled from Amphiphilic Adriamycin-Human Serum Albumin Conjugates for Tumor Targeted Therapy. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057499
American Medical Association (AMA)
Chen, Lin& Chen, Feng& Zhao, Mengxin& Zhu, Xiandi& Ke, Changhong& Yu, Jiangming…[et al.]. A Redox-Sensitive Micelle-Like Nanoparticle Self-Assembled from Amphiphilic Adriamycin-Human Serum Albumin Conjugates for Tumor Targeted Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057499