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Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT
Joint Authors
Gónzalez-Mateo, Guadalupe
Liappas, G.
Sánchez- Tomero, José Antonio
Selgas, Rafael
Aguirre, Anna Rita
Loureiro, Jesús
Abensur, Hugo
Sandoval, Pilar
del Peso, Gloria
Jiménez-Heffernan, José Antonio
Ruiz-Carpio, Vicente
Aguilera Peralta, Abelardo
López-Cabrera, Manuel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Preservation of peritoneal membrane (PM) is essential for long-term survival in peritoneal dialysis (PD).
Continuous presence of PD fluids (PDF) in the peritoneal cavity generates chronic inflammation and promotes changes of the PM, such as fibrosis, angiogenesis, and lymphangiogenesis.
Mesothelial-to-mesenchymal transition (MMT) and endothelial-to-mesenchymal transition (Endo-MT) seem to play a central role in this pathogenesis.
We speculated that Rapamycin, a potent immunosuppressor, could be beneficial by regulating blood and lymphatic vessels proliferation.
We demonstrate that mice undergoing a combined PD and Rapamycin treatment (PDF + Rapa group) presented a reduced PM thickness and lower number of submesothelial blood and lymphatic vessels, as well as decreased MMT and Endo-MT, comparing with their counterparts exposed to PD alone (PDF group).
Peritoneal water transport in the PDF + Rapa group remained at control level, whereas PD effluent levels of VEGF, TGF-β, and TNF-α were lower than in the PDF group.
Moreover, the treatment of mesothelial cells with Rapamycin in vitro significantly decreased VEGF synthesis and selectively inhibited the VEGF-C and VEGF-D release when compared with control cells.
Thus, Rapamycin has a protective effect on PM in PD through an antifibrotic and antiproliferative effect on blood and lymphatic vessels.
Moreover, it inhibits Endo-MT and, at least partially, MMT.
American Psychological Association (APA)
Gónzalez-Mateo, Guadalupe& Aguirre, Anna Rita& Loureiro, Jesús& Abensur, Hugo& Sandoval, Pilar& Sánchez- Tomero, José Antonio…[et al.]. 2015. Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057500
Modern Language Association (MLA)
Gónzalez-Mateo, Guadalupe…[et al.]. Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057500
American Medical Association (AMA)
Gónzalez-Mateo, Guadalupe& Aguirre, Anna Rita& Loureiro, Jesús& Abensur, Hugo& Sandoval, Pilar& Sánchez- Tomero, José Antonio…[et al.]. Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057500