Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Joint Authors
Rao Chamallamudi, Mallikarjuna
Kutty Nampurath, Gopalan
John, Jessy
Nampoothiri, Madhavan
Mudgal, Jayesh
Kumar, Nitesh
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders.
In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex.
Further, the effect of simvastatin treatment on aluminium intoxication was evaluated.
Methods.
Rats were exposed to aluminium chloride (AlCl3) for 60 days.
Simvastatin (10 mg/kg/p.o.) and rivastigmine (1 mg/kg/p.o.) were administered daily prior to AlCl3.
Behavioral parameters were assessed using Morris water maze test and actophotometer followed by biochemical investigations, namely, acetylcholinesterase (AChE) activity, TNF-α level, antioxidant enzymes (GSH, catalase), lipid peroxidation, and nitrite level in hippocampus and frontal cortex.
Triglycerides, total cholesterol, LDL, and HDL levels in serum were also determined.
Key Findings.
Simvastatin treatment improved cognitive function and locomotor activity in rats.
Simvastatin reversed hyperlipidemia and significantly rectified the deleterious effect of AlCl3 on AChE activity.
Further, in hippocampus and frontal cortex, aluminium-induced elevation in nitrite and TNF-α and reduction in antioxidant enzymes were inhibited by simvastatin.
Conclusion.
To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin.
American Psychological Association (APA)
Nampoothiri, Madhavan& John, Jessy& Kumar, Nitesh& Mudgal, Jayesh& Kutty Nampurath, Gopalan& Rao Chamallamudi, Mallikarjuna. 2015. Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057511
Modern Language Association (MLA)
Nampoothiri, Madhavan…[et al.]. Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats. Behavioural Neurology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057511
American Medical Association (AMA)
Nampoothiri, Madhavan& John, Jessy& Kumar, Nitesh& Mudgal, Jayesh& Kutty Nampurath, Gopalan& Rao Chamallamudi, Mallikarjuna. Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057511