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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study
Joint Authors
Teixeira, Manoel Jacobsen
Forlenza, Orestes V.
Drumond Marra, Hellen Livia
Myczkowski, Martin Luiz
Maia Memória, Cláudia
Arnaut, Débora
Leite Ribeiro, Philip
Sardinha Mansur, Carlos Gustavo
Lancelote Alberto, Rodrigo
Boura Bellini, Bianca
Alves Fernandes da Silva, Adriano
Tortella, Gabriel
Ciampi de Andrade, Daniel
Marcolin, Marco Antonio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory.
Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia.
This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI.
We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC).
Thirty-four elderly outpatients meeting Petersen’s MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session.
Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied.
ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction p = 0.05 , favoring the active group.
The improvement was kept after one month.
Other neuropsychological tests were heterogeneous.
rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions.
These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.
American Psychological Association (APA)
Drumond Marra, Hellen Livia& Myczkowski, Martin Luiz& Maia Memória, Cláudia& Arnaut, Débora& Leite Ribeiro, Philip& Sardinha Mansur, Carlos Gustavo…[et al.]. 2015. Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057526
Modern Language Association (MLA)
Drumond Marra, Hellen Livia…[et al.]. Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study. Behavioural Neurology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1057526
American Medical Association (AMA)
Drumond Marra, Hellen Livia& Myczkowski, Martin Luiz& Maia Memória, Cláudia& Arnaut, Débora& Leite Ribeiro, Philip& Sardinha Mansur, Carlos Gustavo…[et al.]. Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1057526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057526