Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation
Joint Authors
Peña-Ortega, Fernando
Salgado-Puga, Karla
Prado-Alcalá, Roberto A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is associated with an early hippocampal dysfunction, which is likely induced by an increase in soluble amyloid beta peptide (Aβ).
This hippocampal failure contributes to the initial memory deficits observed both in patients and in AD animal models and possibly to the deterioration in activities of daily living (ADL).
One typical rodent behavior that has been proposed as a hippocampus-dependent assessment model of ADL in mice and rats is burrowing.
Despite the fact that AD transgenic mice show some evidence of reduced burrowing, it has not been yet determined whether or not Aβ can affect this typical rodent behavior and whether this alteration correlates with the well-known Aβ-induced memory impairment.
Thus, the purpose of this study was to test whether or not Aβ affects burrowing while inducing hippocampus-dependent memory impairment.
Surprisingly, our results show that intrahippocampal application of Aβ increases burrowing while inducing memory impairment.
We consider that this Aβ-induced increase in burrowing might be associated with a mild anxiety state, which was revealed by increased freezing behavior in the open field, and conclude that Aβ-induced hippocampal dysfunction is reflected in the impairment of ADL and memory, through mechanisms yet to be determined.
American Psychological Association (APA)
Salgado-Puga, Karla& Prado-Alcalá, Roberto A.& Peña-Ortega, Fernando. 2015. Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation. Behavioural Neurology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057549
Modern Language Association (MLA)
Salgado-Puga, Karla…[et al.]. Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation. Behavioural Neurology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057549
American Medical Association (AMA)
Salgado-Puga, Karla& Prado-Alcalá, Roberto A.& Peña-Ortega, Fernando. Amyloid β Enhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation. Behavioural Neurology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057549