Synthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats
Joint Authors
Gopalakrishnan, Veerasamy
Iyyam Pillai, Subramanian
Subramanian, Sorimuthu Pillai
Source
Biochemistry Research International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In view of the established antidiabetic properties of zinc, the present study was aimed at evaluating the hypoglycemic properties of a new zinc-diosmin complex in high fat diet fed-low dose streptozotocin induced experimental type 2 diabetes in rats.
Zinc-diosmin complex was synthesized and characterized by various spectral studies.
The complexation between zinc ions and diosmin was further evidenced by pH-potentiometric titrations and Job’s plot.
Diabetic rats were orally treated with zinc-diosmin complex at a concentration of 20 mg/kg b.w./rat/day for 30 days.
At the end of the experimental period, the rats were subjected to oral glucose tolerance test.
In addition, HOMA-IR and various biochemical parameters related to glucose homeostasis were analyzed.
Treatment with zinc-diosmin complex significantly improved the glucose homeostasis in diabetic rats.
Treatment with zinc-diosmin complex significantly improved insulin sensitivity, at least in part, through enhancing protein metabolism and alteration in the levels of muscle and liver glycogen.
The assay of clinical marker enzymes revealed the nontoxic nature of the complex.
Determination of renal tissue markers such as blood urea and serum creatinine indicates the renoprotective nature of the complex.
These findings suggest that zinc-diosmin complex is nontoxic and has complimentary potential to develop as an antihyperglycemic agent for the treatment of diabetes mellitus.
American Psychological Association (APA)
Gopalakrishnan, Veerasamy& Iyyam Pillai, Subramanian& Subramanian, Sorimuthu Pillai. 2015. Synthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats. Biochemistry Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057612
Modern Language Association (MLA)
Gopalakrishnan, Veerasamy…[et al.]. Synthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats. Biochemistry Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057612
American Medical Association (AMA)
Gopalakrishnan, Veerasamy& Iyyam Pillai, Subramanian& Subramanian, Sorimuthu Pillai. Synthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats. Biochemistry Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057612