Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors
Joint Authors
Fedurco, Milan
Gregorová, Jana
Šebrlová, Kristýna
Kantorová, Jana
Peš, Ondřej
Baur, Roland
Sigel, Erwin
Táborská, Eva
Source
Biochemistry Research International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant.
Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries.
However, our understanding of these biological effects at the molecular level is still lacking.
Alkaloids detected in E.
californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons.
Electrophysiological studies on a recombinant α1β2γ2 GABAA receptor showed no effect of N-methyllaurotetanine at concentrations lower than 30 μM.
However, (S)-reticuline behaved as positive allosteric modulator at the α3, α5, and α6 isoforms of GABAA receptors.
The depressant properties of aerial parts of E.
californica are assigned to chloride-current modulation by (S)-reticuline at the α3β2γ2 and α5β2γ2 GABAA receptors.
Interestingly, α1, α3, and α5 were not significantly affected by (R)-reticuline, 1,2-tetrahydroreticuline, codeine, and morphine—suspected (S)-reticuline metabolites in the rodent brain.
American Psychological Association (APA)
Fedurco, Milan& Gregorová, Jana& Šebrlová, Kristýna& Kantorová, Jana& Peš, Ondřej& Baur, Roland…[et al.]. 2015. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochemistry Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057618
Modern Language Association (MLA)
Fedurco, Milan…[et al.]. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochemistry Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057618
American Medical Association (AMA)
Fedurco, Milan& Gregorová, Jana& Šebrlová, Kristýna& Kantorová, Jana& Peš, Ondřej& Baur, Roland…[et al.]. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochemistry Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057618