![](/images/graphics-bg.png)
Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
Joint Authors
Damiani, Mario Francesco
Carratù, Pierluigi
Falcone, Vito Antonio
Bega, Elioda
Ciccone, Marco Matteo
Resta, Onofrio
Zito, Annapaola
Scicchitano, Pietro
Source
Biochemistry Research International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis.
Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis.
However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied.
The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3).
Methods.
The study design allowed us to define 4 groups: (1) controls (n=30); (2) OSA patients without HTN (n=30); (3) HTN patients without OSA (n=30); (4) patients with OSA and HTN (n=30).
In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured.
Results.
Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects.
Conclusions.
OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.
American Psychological Association (APA)
Damiani, Mario Francesco& Zito, Annapaola& Carratù, Pierluigi& Falcone, Vito Antonio& Bega, Elioda& Scicchitano, Pietro…[et al.]. 2015. Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis. Biochemistry Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057628
Modern Language Association (MLA)
Damiani, Mario Francesco…[et al.]. Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis. Biochemistry Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057628
American Medical Association (AMA)
Damiani, Mario Francesco& Zito, Annapaola& Carratù, Pierluigi& Falcone, Vito Antonio& Bega, Elioda& Scicchitano, Pietro…[et al.]. Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis. Biochemistry Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057628