Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases
Joint Authors
Li, Yixue
Cui, Peng
Zhang, Menghuan
Xie, Lu
Sun, Bo
Li, Hong
Jia, Jia
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Protein posttranslational modifications (PTMs) play key roles in a variety of protein activities and cellular processes.
Different PTMs show distinct impacts on protein functions, and normal protein activities are consequences of all kinds of PTMs working together.
With the development of high throughput technologies such as tandem mass spectrometry (MS/MS) and next generation sequencing, more and more nonsynonymous single-nucleotide variations (nsSNVs) that cause variation of amino acids have been identified, some of which result in the damage of PTMs.
The damaged PTMs could be the reason of the development of some human diseases.
In this study, we elucidated the proteome wide relationship of eight damaged PTMs to human inherited diseases and cancers.
Some human inherited diseases or cancers may be the consequences of the interactions of damaged PTMs, rather than the result of single damaged PTM site.
American Psychological Association (APA)
Sun, Bo& Zhang, Menghuan& Cui, Peng& Li, Hong& Jia, Jia& Li, Yixue…[et al.]. 2015. Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057801
Modern Language Association (MLA)
Sun, Bo…[et al.]. Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057801
American Medical Association (AMA)
Sun, Bo& Zhang, Menghuan& Cui, Peng& Li, Hong& Jia, Jia& Li, Yixue…[et al.]. Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057801