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Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests
Joint Authors
Shan, Guogen
Amei, Amei
Young, Daniel
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sensitivity and specificity are often used to assess the performance of a diagnostic test with binary outcomes.
Wald-type test statistics have been proposed for testing sensitivity and specificity individually.
In the presence of a gold standard, simultaneous comparison between two diagnostic tests for noninferiority of sensitivity and specificity based on an asymptotic approach has been studied by Chen et al.
(2003).
However, the asymptotic approach may suffer from unsatisfactory type I error control as observed from many studies, especially in small to medium sample settings.
In this paper, we compare three unconditional approaches for simultaneously testing sensitivity and specificity.
They are approaches based on estimation, maximization, and a combination of estimation and maximization.
Although the estimation approach does not guarantee type I error, it has satisfactory performance with regard to type I error control.
The other two unconditional approaches are exact.
The approach based on estimation and maximization is generally more powerful than the approach based on maximization.
American Psychological Association (APA)
Shan, Guogen& Amei, Amei& Young, Daniel. 2015. Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057803
Modern Language Association (MLA)
Shan, Guogen…[et al.]. Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057803
American Medical Association (AMA)
Shan, Guogen& Amei, Amei& Young, Daniel. Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057803