Network-Based Inference Methods for Drug Repositioning
Joint Authors
Chen, Hailin
Zhang, Zuping
Zhang, Heng
Cao, Yiqin
Tang, Wenliang
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mining potential drug-disease associations can speed up drug repositioning for pharmaceutical companies.
Previous computational strategies focused on prior biological information for association inference.
However, such information may not be comprehensively available and may contain errors.
Different from previous research, two inference methods, ProbS and HeatS, were introduced in this paper to predict direct drug-disease associations based only on the basic network topology measure.
Bipartite network topology was used to prioritize the potentially indicated diseases for a drug.
Experimental results showed that both methods can receive reliable prediction performance and achieve AUC values of 0.9192 and 0.9079, respectively.
Case studies on real drugs indicated that some of the strongly predicted associations were confirmed by results in the Comparative Toxicogenomics Database (CTD).
Finally, a comprehensive prediction of drug-disease associations enables us to suggest many new drug indications for further studies.
American Psychological Association (APA)
Chen, Hailin& Zhang, Heng& Zhang, Zuping& Cao, Yiqin& Tang, Wenliang. 2015. Network-Based Inference Methods for Drug Repositioning. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057804
Modern Language Association (MLA)
Chen, Hailin…[et al.]. Network-Based Inference Methods for Drug Repositioning. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057804
American Medical Association (AMA)
Chen, Hailin& Zhang, Heng& Zhang, Zuping& Cao, Yiqin& Tang, Wenliang. Network-Based Inference Methods for Drug Repositioning. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057804