Monte Carlo Calculation of Radioimmunotherapy with 90Y-, 177Lu-, 131I-, 124I-, and 188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts
Joint Authors
Gallez, Bernard
Feron, O.
Masereel, B.
Michiels, C.
Vander Borght, T.
Lucas, S.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like 131I or 90Y still remains ineffective for solid and radioresistant tumour treatment.
Previous simulations have revealed that an increase in the number of 90Y labelled to each antibody or nanoobject could be a solution to improve treatment output.
It now seems important to assess the treatment output and toxicity when radionuclides such as 90Y, 177Lu, 131I, 124I, and 188Re are used.
Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects.
Analyses were carried out for two solid tumour sizes of 0.5 and 1.0 cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)).
90Y and 188Re are the best candidates for solid tumour treatment when only one radionuclide is coupled to one carrier.
Furthermore, regardless of the radionuclide properties, high values of TCP can be reached without toxicity if the number of radionuclides per nanoobject increases.
American Psychological Association (APA)
Lucas, S.& Feron, O.& Gallez, Bernard& Masereel, B.& Michiels, C.& Vander Borght, T.. 2015. Monte Carlo Calculation of Radioimmunotherapy with 90Y-, 177Lu-, 131I-, 124I-, and 188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057855
Modern Language Association (MLA)
Lucas, S.…[et al.]. Monte Carlo Calculation of Radioimmunotherapy with 90Y-, 177Lu-, 131I-, 124I-, and 188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057855
American Medical Association (AMA)
Lucas, S.& Feron, O.& Gallez, Bernard& Masereel, B.& Michiels, C.& Vander Borght, T.. Monte Carlo Calculation of Radioimmunotherapy with 90Y-, 177Lu-, 131I-, 124I-, and 188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057855