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Genetic Consequences of Antiviral Therapy on HIV-1
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A variety of enzyme inhibitors have been developed in combating HIV-1, however the fast evolutionary rate of this virus commonly leads to the emergence of resistance mutations that finally allows the mutant virus to survive.
This review explores the main genetic consequences of HIV-1 molecular evolution during antiviral therapies, including the viral genetic diversity and molecular adaptation.
The role of recombination in the generation of drug resistance is also analyzed.
Besides the investigation and discussion of published works, an evolutionary analysis of protease-coding genes collected from patients before and after treatment with different protease inhibitors was included to validate previous studies.
Finally, the review discusses the importance of considering genetic consequences of antiviral therapies in models of HIV-1 evolution that could improve current genotypic resistance testing and treatments design.
American Psychological Association (APA)
Arenas, Miguel. 2015. Genetic Consequences of Antiviral Therapy on HIV-1. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057886
Modern Language Association (MLA)
Arenas, Miguel. Genetic Consequences of Antiviral Therapy on HIV-1. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057886
American Medical Association (AMA)
Arenas, Miguel. Genetic Consequences of Antiviral Therapy on HIV-1. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057886