PET-Specific Parameters and Radiotracers in Theoretical Tumour Modelling
Joint Authors
Bezak, Eva
Jennings, Matthew
Marcu, Loredana G.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The innovation of computational techniques serves as an important step toward optimized, patient-specific management of cancer.
In particular, in silico simulation of tumour growth and treatment response may eventually yield accurate information on disease progression, enhance the quality of cancer treatment, and explain why certain therapies are effective where others are not.
In silico modelling is demonstrated to considerably benefit from information obtainable with PET and PET/CT.
In particular, models have successfully integrated tumour glucose metabolism, cell proliferation, and cell oxygenation from multiple tracers in order to simulate tumour behaviour.
With the development of novel radiotracers to image additional tumour phenomena, such as pH and gene expression, the value of PET and PET/CT data for use in tumour models will continue to grow.
In this work, the use of PET and PET/CT information in in silico tumour models is reviewed.
The various parameters that can be obtained using PET and PET/CT are detailed, as well as the radiotracers that may be used for this purpose, their utility, and limitations.
The biophysical measures used to quantify PET and PET/CT data are also described.
Finally, a list of in silico models that incorporate PET and/or PET/CT data is provided and reviewed.
American Psychological Association (APA)
Jennings, Matthew& Marcu, Loredana G.& Bezak, Eva. 2015. PET-Specific Parameters and Radiotracers in Theoretical Tumour Modelling. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057890
Modern Language Association (MLA)
Jennings, Matthew…[et al.]. PET-Specific Parameters and Radiotracers in Theoretical Tumour Modelling. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057890
American Medical Association (AMA)
Jennings, Matthew& Marcu, Loredana G.& Bezak, Eva. PET-Specific Parameters and Radiotracers in Theoretical Tumour Modelling. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057890