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Detection of Dendritic Spines Using Wavelet-Based Conditional Symmetric Analysis and Regularized Morphological Shared-Weight Neural Networks
Joint Authors
Wang, Shuihua
Chen, Mengmeng
Li, Yang
Zhang, Yudong
Han, Liangxiu
Wu, Jane
Du, Sidan
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Identification and detection of dendritic spines in neuron images are of high interest in diagnosis and treatment of neurological and psychiatric disorders (e.g., Alzheimer’s disease, Parkinson’s diseases, and autism).
In this paper, we have proposed a novel automatic approach using wavelet-based conditional symmetric analysis and regularized morphological shared-weight neural networks (RMSNN) for dendritic spine identification involving the following steps: backbone extraction, localization of dendritic spines, and classification.
First, a new algorithm based on wavelet transform and conditional symmetric analysis has been developed to extract backbone and locate the dendrite boundary.
Then, the RMSNN has been proposed to classify the spines into three predefined categories (mushroom, thin, and stubby).
We have compared our proposed approach against the existing methods.
The experimental result demonstrates that the proposed approach can accurately locate the dendrite and accurately classify the spines into three categories with the accuracy of 99.1% for “mushroom” spines, 97.6% for “stubby” spines, and 98.6% for “thin” spines.
American Psychological Association (APA)
Wang, Shuihua& Chen, Mengmeng& Li, Yang& Zhang, Yudong& Han, Liangxiu& Wu, Jane…[et al.]. 2015. Detection of Dendritic Spines Using Wavelet-Based Conditional Symmetric Analysis and Regularized Morphological Shared-Weight Neural Networks. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057904
Modern Language Association (MLA)
Wang, Shuihua…[et al.]. Detection of Dendritic Spines Using Wavelet-Based Conditional Symmetric Analysis and Regularized Morphological Shared-Weight Neural Networks. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057904
American Medical Association (AMA)
Wang, Shuihua& Chen, Mengmeng& Li, Yang& Zhang, Yudong& Han, Liangxiu& Wu, Jane…[et al.]. Detection of Dendritic Spines Using Wavelet-Based Conditional Symmetric Analysis and Regularized Morphological Shared-Weight Neural Networks. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057904