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Cell Pluripotency Levels Associated with Imprinted Genes in Human
Joint Authors
Ding, Guohui
Yuan, Liyun
Tang, Xiaoyan
Zhang, Binyan
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pluripotent stem cells are exhibited similarly in the morphology, gene expression, growth properties, and epigenetic modification with embryonic stem cells (ESCs).
However, it is still controversial that the pluripotency of induced pluripotent stem cell (iPSC) is much inferior to ESC, and the differentiation capacity of iPSC and ESC can also be separated by transcriptome and epigenetics.
miRNAs, which act in posttranscriptional regulation of gene expression and are involved in many basic cellular processes, may reveal the answer.
In this paper, we focused on identifying the hidden relationship between miRNAs and imprinted genes in cell pluripotency.
Total miRNA expression patterns in iPSC and ES cells were comprehensively analysed and linked with human imprinted genes, which show a global picture of their potential function in pluripotent level.
A new CPA4-KLF14 region which locates in chromosomal homologous segments (CHSs) within mammals and include both imprinted genes and significantly expressed miRNAs was first identified.
Molecular network analysis showed genes interacted with imprinted genes closely and enriched in modules such as cancer, cell death and survival, and tumor morphology.
This imprinted region may provide a new look for those who are interested in cell pluripotency of hiPSCs and hESCs.
American Psychological Association (APA)
Yuan, Liyun& Tang, Xiaoyan& Zhang, Binyan& Ding, Guohui. 2015. Cell Pluripotency Levels Associated with Imprinted Genes in Human. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057909
Modern Language Association (MLA)
Yuan, Liyun…[et al.]. Cell Pluripotency Levels Associated with Imprinted Genes in Human. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057909
American Medical Association (AMA)
Yuan, Liyun& Tang, Xiaoyan& Zhang, Binyan& Ding, Guohui. Cell Pluripotency Levels Associated with Imprinted Genes in Human. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057909