Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector
Joint Authors
Bezak, Eva
AL Darwish, Ruqaya
Staudacher, Alexander Hugo
Brown, Michael Paul
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy.
These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells.
Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector.
We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector.
Additionally, the sensitivity of the Timepix detector to monitor variations in tumour uptake based on the necrotic tissue volume was also studied.
Compartmental analysis model was used, based on the obtained imaging data, to assess the Th-227 uptake.
Results show that alpha particle, photon, electron, and muon tracks were detected and resolved by Timepix detector.
The current study demonstrated that individual alpha particle emissions, resulting from targeted alpha therapy, can be visualised and quantified using Timepix detector.
Furthermore, the variations in the uptake based on the tumour necrotic volume have been observed with four times higher uptake for tumours pretreated with chemotherapy than for those without chemotherapy.
American Psychological Association (APA)
AL Darwish, Ruqaya& Staudacher, Alexander Hugo& Bezak, Eva& Brown, Michael Paul. 2015. Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057954
Modern Language Association (MLA)
AL Darwish, Ruqaya…[et al.]. Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057954
American Medical Association (AMA)
AL Darwish, Ruqaya& Staudacher, Alexander Hugo& Bezak, Eva& Brown, Michael Paul. Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057954