Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma
Joint Authors
Nan, Ke-Jun
Hao, Yibin
Fan, Tianli
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To optimize and verify the regulatory pathway of p42.3 in the pathogenesis of gastric carcinoma (GC) by intelligent algorithm.
Methods.
Bioinformatics methods were used to analyze the features of structural domain in p42.3 protein.
Proteins with the same domains and similar functions to p42.3 were screened out for reference.
The possible regulatory pathway of p42.3 was established by integrating the acting pathways of these proteins.
Then, the similarity between the reference proteins and p42.3 protein was figured out by multiparameter weighted summation method.
The calculation result was taken as the prior probability of the initial node in Bayesian network.
Besides, the probability of occurrence in different pathways was calculated by conditional probability formula, and the one with the maximum probability was regarded as the most possible pathway of p42.3.
Finally, molecular biological experiments were conducted to prove it.
Results.
In Bayesian network of p42.3, probability of the acting pathway “S100A11→RAGE→P38→MAPK→Microtubule-associated protein→Spindle protein→Centromere protein→Cell proliferation” was the biggest, and it was also validated by biological experiments.
Conclusions.
The possibly important role of p42.3 in the occurrence of gastric carcinoma was verified by theoretical analysis and preliminary test, helping in studying the relationship between p42.3 and gastric carcinoma.
American Psychological Association (APA)
Hao, Yibin& Fan, Tianli& Nan, Ke-Jun. 2015. Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057972
Modern Language Association (MLA)
Hao, Yibin…[et al.]. Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057972
American Medical Association (AMA)
Hao, Yibin& Fan, Tianli& Nan, Ke-Jun. Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057972