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Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes
Joint Authors
Bozkurt, Yasemin
Demir, Alper
Erman, Burak
Gül, Ahmet
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Familial mediterranean fever (FMF) and Cryopyrin associated periodic syndromes (CAPS) are two prototypical hereditary autoinflammatory diseases, characterized by recurrent episodes of fever and inflammation as a result of mutations in MEFV and NLRP3 genes encoding Pyrin and Cryopyrin proteins, respectively.
Pyrin and Cryopyrin play key roles in the multiprotein inflammasome complex assembly, which regulates activity of an enzyme, Caspase 1, and its target cytokine, IL-1β.
Overproduction of IL-1β by Caspase 1 is the main cause of episodic fever and inflammatory findings in FMF and CAPS.
We present a unifying dynamical model for FMF and CAPS in the form of coupled nonlinear ordinary differential equations.
The model is composed of two subsystems, which capture the interactions and dynamics of the key molecular players and the insults on the immune system.
One of the subsystems, which contains a coupled positive-negative feedback motif, captures the dynamics of inflammation formation and regulation.
We perform a comprehensive bifurcation analysis of the model and show that it exhibits three modes, capturing the Healthy, FMF, and CAPS cases.
The mutations in Pyrin and Cryopyrin are reflected in the values of three parameters in the model.
We present extensive simulation results for the model that match clinical observations.
American Psychological Association (APA)
Bozkurt, Yasemin& Demir, Alper& Erman, Burak& Gül, Ahmet. 2015. Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1058026
Modern Language Association (MLA)
Bozkurt, Yasemin…[et al.]. Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1058026
American Medical Association (AMA)
Bozkurt, Yasemin& Demir, Alper& Erman, Burak& Gül, Ahmet. Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1058026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058026