A Report of Accelerated Coronary Artery Disease Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Joint Authors
Rubin, Courtney B.
Hahn, Virginia
Kobayashi, Taisei
Litwack, Andrew
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable form of vascular dementia and it is caused by mutations in the NOTCH3 gene.
The neurologic manifestations of CADASIL syndrome have been well characterized; however, here we report one of the first de novo cases of CADASIL-associated coronary artery disease.
A 45-year-old woman with a history of CADASIL and remote tobacco use presented with unstable angina.
She was found to have diffuse and irregular narrowing of the left anterior descending artery and a drug eluting stent was deployed.
Months later, she developed two subsequent episodes of unstable angina, requiring stent placement in the distal left anterior descending artery and the right coronary artery.
Though the neurologic manifestations of CADASIL have been well described, these patients may also be predisposed to developing premature coronary artery disease.
Patients with CADASIL and their physicians should be aware of this possible association because these patients may not be identified as high risk by traditional cardiovascular risk estimators.
These patients may benefit from more aggressive interventions to reduce cardiac risk.
American Psychological Association (APA)
Rubin, Courtney B.& Hahn, Virginia& Kobayashi, Taisei& Litwack, Andrew. 2015. A Report of Accelerated Coronary Artery Disease Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Case Reports in Cardiology،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058084
Modern Language Association (MLA)
Rubin, Courtney B.…[et al.]. A Report of Accelerated Coronary Artery Disease Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Case Reports in Cardiology No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058084
American Medical Association (AMA)
Rubin, Courtney B.& Hahn, Virginia& Kobayashi, Taisei& Litwack, Andrew. A Report of Accelerated Coronary Artery Disease Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Case Reports in Cardiology. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058084