Thrombus Formation in Left Atrium on Dabigatran Therapy
Joint Authors
Shah, Priyank
Mithawala, Priyam
Konlian, Donna
Soyombo, Aderemi
Bikkina, Mahesh
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Dabigatran is a direct thrombin inhibitor, approved in the United States for stroke prevention in nonvalvular atrial fibrillation and prevention and treatment of thromboembolism.
It has been also used in patients with documented left atrial thrombus, where treatment with dabigatran effectively led to thrombus resolution.
We present a rare case of left atrial thrombus formation in a patient with chronic atrial fibrillation being treated with dabigatran 150 mg twice a day.
The patient presented with multiple embolic strokes.
There are only three such cases reported in the literature till date, all of whom had thrombus in the left atrium.
The possible mechanisms of dabigatran failure include compensatory increase in upstream coagulation factors due to single level downstream blockade of thrombin, lack of inhibition of all available thrombin, and lack of monitoring measures that can be implemented in common clinical laboratories that lead to failure to assess adherence, which in turn can lead to dabigatran failure.
American Psychological Association (APA)
Shah, Priyank& Mithawala, Priyam& Konlian, Donna& Soyombo, Aderemi& Bikkina, Mahesh. 2015. Thrombus Formation in Left Atrium on Dabigatran Therapy. Case Reports in Cardiology،Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1058124
Modern Language Association (MLA)
Shah, Priyank…[et al.]. Thrombus Formation in Left Atrium on Dabigatran Therapy. Case Reports in Cardiology No. 2015 (2015), pp.1-2.
https://search.emarefa.net/detail/BIM-1058124
American Medical Association (AMA)
Shah, Priyank& Mithawala, Priyam& Konlian, Donna& Soyombo, Aderemi& Bikkina, Mahesh. Thrombus Formation in Left Atrium on Dabigatran Therapy. Case Reports in Cardiology. 2015. Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1058124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058124