Megace Mystery: A Case of Central Adrenal Insufficiency
Joint Authors
Mehta, Kunal
Weiss, Irene
Goldberg, Michael D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Megestrol acetate (MA) is a synthetic progestin with both antineoplastic and orexigenic properties.
In addition to its effects on the progesterone receptor, MA also binds the glucocorticoid receptor.
Some patients receiving MA therapy have been reported to develop clinical features of glucocorticoid excess, while others have experienced the clinical syndrome of cortisol deficiency—either following withdrawal of MA therapy or during active treatment.
We describe a patient who presented with clinical and biochemical features of central adrenal insufficiency.
Pituitary function was otherwise essentially normal, and the etiology of the isolated ACTH suppression was initially unclear.
The use of an exogenous glucocorticoid was suspected but was initially denied by the patient; ultimately, the culprit medication was uncovered when a synthetic steroid screen revealed the presence of MA.
The patient’s symptoms improved after she was switched to hydrocortisone.
Clinicians should be aware of the potential effects of MA on the hypothalamic-pituitary-adrenal (HPA) axis.
American Psychological Association (APA)
Mehta, Kunal& Weiss, Irene& Goldberg, Michael D.. 2015. Megace Mystery: A Case of Central Adrenal Insufficiency. Case Reports in Endocrinology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058388
Modern Language Association (MLA)
Mehta, Kunal…[et al.]. Megace Mystery: A Case of Central Adrenal Insufficiency. Case Reports in Endocrinology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058388
American Medical Association (AMA)
Mehta, Kunal& Weiss, Irene& Goldberg, Michael D.. Megace Mystery: A Case of Central Adrenal Insufficiency. Case Reports in Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058388