Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review
Joint Authors
Majchel, Deborah
Korytkowski, Mary T.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We describe a case of autoimmune hypophysitis induced by the anticytotoxic T-lymphocyte antigen-4 (CTLA-4) agent, ipilimumab.
Methods.
Case presentation and review of the literature.
Results.
Autoimmune hypophysitis, a previously described rare disorder, is being recognized more frequently as a side effect of novel immunomodulatory agents used in the treatment of malignancies such as melanoma.
CTLA-4 agents are associated with immune-related adverse effects (irAE) which occur as a result of activation (or lack of inactivation) of the immune response.
This impacts not only malignant cells but also different host organ-systems.
Autoimmune hypophysitis is one of several endocrinopathies associated with these agents.
Conclusion.
It is important that endocrinologists become familiar with the endocrinopathies, such as autoimmune hypophysitis, associated with new immunomodulator agents which are being used with increasing frequency to treat a variety of malignancies.
American Psychological Association (APA)
Majchel, Deborah& Korytkowski, Mary T.. 2015. Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review. Case Reports in Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058407
Modern Language Association (MLA)
Majchel, Deborah& Korytkowski, Mary T.. Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review. Case Reports in Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1058407
American Medical Association (AMA)
Majchel, Deborah& Korytkowski, Mary T.. Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review. Case Reports in Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058407