Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid
Joint Authors
LaBryer, Lauren
Sawh, Ravindranauth
McLaurin, Colby
Scofield, R. Hal
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary neuroendocrine tumors of the larynx are rare, with moderately differentiated neuroendocrine carcinoma (MDNC) being the most frequent histologic type.
We report a MDNC in a 57-year-old gentleman with an enlarging right-sided neck mass.
Flexible fiberoptic exam revealed a right arytenoid lesion.
Histology from excisional biopsy was concerning for medullary thyroid carcinoma (MTC) versus NET of the larynx.
Immunohistochemistry was diffusely positive for calcitonin and CEA and focally positive for TTF-1.
Serum calcitonin was elevated.
Thyroid ultrasound was unremarkable.
The patient underwent laryngectomy, thyroidectomy, and neck dissection.
Pathology showed neuroendocrine carcinoma of right arytenoid with positive cervical lymph nodes.
A 4 mm deposit of NET was present in right thyroid with adjacent intravascular tumor consistent with thyroidal metastasis from a primary laryngeal NET (MDNC).
MDNC and MTC can be microscopically indistinguishable.
Both tumors can stain positively for calcitonin and CEA.
TTF-1 staining has been useful to help distinguish these tumors as it is strongly and diffusely positive in MTC, but usually negative (or only focally positive) in MDNC.
We report the fourth case of primary neuroendocrine carcinoma of the larynx associated with elevated serum calcitonin level and the first such case associated with metastasis to the thyroid.
American Psychological Association (APA)
LaBryer, Lauren& Sawh, Ravindranauth& McLaurin, Colby& Scofield, R. Hal. 2015. Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid. Case Reports in Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058408
Modern Language Association (MLA)
LaBryer, Lauren…[et al.]. Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid. Case Reports in Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1058408
American Medical Association (AMA)
LaBryer, Lauren& Sawh, Ravindranauth& McLaurin, Colby& Scofield, R. Hal. Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid. Case Reports in Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058408