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Dipeptidyl Peptidase-4 Inhibition May Stimulate Progression of Carcinoid Tumor
Joint Authors
Pech, Vladimir
Abusaada, Khalid
Alemany, Carlos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-28
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as saxagliptin, have gained a rapid growth in use in the treatment of type 2 diabetes mellitus in the past decade.
Although they are considered to have a good safety profile, controversy exists regarding their potential to stimulate neoplasm growth.
We report here a patient with metastatic carcinoid tumor.
His disease was stable for several years with plasma serotonin level (which was used to monitor disease progression) in 700–800 ng/mL range.
After initiation of treatment with saxagliptin, however, his serotonin level almost doubled (1358 ng/mL), concerning progression of the disease.
After discontinuation of saxagliptin, serotonin level returned to baseline quickly, while other laboratory markers, such as complete blood count (CBC), comprehensive metabolic profile (CMP) with liver function tests (LFTs), and lactate dehydrogenase (LD), remained unchanged before, during, and after the treatment with saxagliptin.
This temporal correlation suggests a possible interaction between the activity of carcinoid tumors and the use of DPP-4 inhibitors.
Although we were not able to find any literature providing a direct evidence that saxagliptin alters progression of the carcinoid tumors, we recommend alternative management for the treatment of diabetes in patients with carcinoid or other neuroendocrine tumors.
American Psychological Association (APA)
Pech, Vladimir& Abusaada, Khalid& Alemany, Carlos. 2015. Dipeptidyl Peptidase-4 Inhibition May Stimulate Progression of Carcinoid Tumor. Case Reports in Endocrinology،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058432
Modern Language Association (MLA)
Pech, Vladimir…[et al.]. Dipeptidyl Peptidase-4 Inhibition May Stimulate Progression of Carcinoid Tumor. Case Reports in Endocrinology No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058432
American Medical Association (AMA)
Pech, Vladimir& Abusaada, Khalid& Alemany, Carlos. Dipeptidyl Peptidase-4 Inhibition May Stimulate Progression of Carcinoid Tumor. Case Reports in Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058432