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Upper Gastrointestinal Bleeding from Gastric Amyloidosis in a Patient with Smoldering Multiple Myeloma
Joint Authors
Gjeorgjievski, Mihajlo
Purohit, Treta
Kurtin, Paul J.
Cappell, Mitchell S.
Amin, Mitual
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Amyloidosis is a common complication of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma (MM).
This proteinaceous material can be deposited intercellularly in any organ system, including the gastrointestinal (GI) tract.
In the GI tract, amyloidosis affects the duodenum most commonly, followed by the stomach and colorectum.
Gastric amyloidosis causes symptoms of nausea, vomiting, early satiety, abdominal pain, and GI bleeding.
A case of upper GI bleeding from gastric amyloidosis is presented in a patient with SMM.
Esophagogastroduodenoscopy (EGD) revealed a gastric mass.
Endoscopic biopsies revealed amyloid deposition in the lamina propria, consistent with gastric amyloidosis.
Liquid chromatography tandem mass spectrometry performed on peptides extracted from Congo red-positive microdissected areas of paraffin-embedded stomach specimens revealed a peptide profile consistent with AL- (lambda-) type amyloidosis.
Based on this and multiple other case reports, we recommend that patients with GI bleeding and MGUS, SMM, or MM undergo EGD and pathologic examination of endoscopic biopsies of identified lesions using Congo red stains for amyloidosis for early diagnosis and treatment.
American Psychological Association (APA)
Gjeorgjievski, Mihajlo& Purohit, Treta& Amin, Mitual& Kurtin, Paul J.& Cappell, Mitchell S.. 2015. Upper Gastrointestinal Bleeding from Gastric Amyloidosis in a Patient with Smoldering Multiple Myeloma. Case Reports in Gastrointestinal Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058534
Modern Language Association (MLA)
Gjeorgjievski, Mihajlo…[et al.]. Upper Gastrointestinal Bleeding from Gastric Amyloidosis in a Patient with Smoldering Multiple Myeloma. Case Reports in Gastrointestinal Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1058534
American Medical Association (AMA)
Gjeorgjievski, Mihajlo& Purohit, Treta& Amin, Mitual& Kurtin, Paul J.& Cappell, Mitchell S.. Upper Gastrointestinal Bleeding from Gastric Amyloidosis in a Patient with Smoldering Multiple Myeloma. Case Reports in Gastrointestinal Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058534