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Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine
Joint Authors
Soape, Matthew P.
Verma, Rashmi
Hardwicke, Fred
Cobos, E.
Payne, Drew
Wachtel, Mitchell
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hepatic epithelioid hemangioendothelioma (HEH) is extremely rare, occurring in 1 to 2 per 100,000, with chemotherapy options not well defined.
Our case involved a 49-year-old female who had hepatic masses and metastasis to the lungs with a liver biopsy revealing HEH.
After developing a rash from sorafenib, thalidomide was started with the progression of disease stabilized.
Resection is only an option in 10% of the cases; therefore, chemotherapy is the only line of treatment.
Newer chemotherapy alternatives are targeting angiogenesis via the vascular endothelial growth factor.
Thalidomide was first used as an antiemetic, but, sadly, soon linked to phocomelia birth defects.
Given the mechanism of action against angiogenesis, thalidomide has a valid role in vascular tumors.
In conclusion, the use of thalidomide as chemotherapy is novel and promising, especially in the setting of a rare vascular liver tumor such as HEH.
American Psychological Association (APA)
Soape, Matthew P.& Verma, Rashmi& Payne, Drew& Wachtel, Mitchell& Hardwicke, Fred& Cobos, E.. 2015. Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine. Case Reports in Gastrointestinal Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058535
Modern Language Association (MLA)
Soape, Matthew P.…[et al.]. Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine. Case Reports in Gastrointestinal Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058535
American Medical Association (AMA)
Soape, Matthew P.& Verma, Rashmi& Payne, Drew& Wachtel, Mitchell& Hardwicke, Fred& Cobos, E.. Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine. Case Reports in Gastrointestinal Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058535