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De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly
Joint Authors
Al Mussaed, Eman
Alzahrani, Ali Matar
Aljasem, Hassan
Alotaibi, Sultan
Elghezal, Hatem
Elyamany, Ghaleb
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The recent World Health Organization (WHO) classification defines mantle cell lymphoma (MCL) as a distinct entity characterized by a unique immunophenotype and a molecular hallmark of chromosomal translocation t(11;14)(q13;q32).
We report an unusual case of an advanced stage of CD5 negative MCL with a blastoid variant with a massive bone marrow (BM) necrosis as an initial presenting feature, with no adenopathy or hepatosplenomegaly.
The pathologic features showed blastoid variant of MCL and flow cytometry showed that the tumor cells were CD5−, CD19+, CD20+, FMC-7+, CD23−, and lambda light chain restricted.
Chromosomal analysis, using karyotype and fluorescent in situ hybridization (FISH), demonstrated karyotypic abnormalities in addition to the t(11;14).
Our case study may be reported as a unique case of CD5− blastic MCL with unusual presentation and findings which made the diagnosis of MCL difficult.
American Psychological Association (APA)
Elyamany, Ghaleb& Alzahrani, Ali Matar& Al Mussaed, Eman& Aljasem, Hassan& Alotaibi, Sultan& Elghezal, Hatem. 2015. De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058578
Modern Language Association (MLA)
Elyamany, Ghaleb…[et al.]. De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly. Case Reports in Hematology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1058578
American Medical Association (AMA)
Elyamany, Ghaleb& Alzahrani, Ali Matar& Al Mussaed, Eman& Aljasem, Hassan& Alotaibi, Sultan& Elghezal, Hatem. De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058578