Sirolimus-Based Immunosuppression as GvHD Prophylaxis after Bone Marrow Transplantation for Severe Aplastic Anaemia: A Case Report and Review of the Literature
Joint Authors
Capolsini, Ilaria
Caniglia, Maurizio
Mastrodicasa, Elena
Gurdo, Grazia
Cerri, Carla
Perruccio, Katia
Arcioni, Francesco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Congenital or acquired severe aplastic anaemia (SAA) is cured by bone marrow transplantation (BMT) from a histocompatible leukocyte antigen- (HLA-) identical sibling.
The best conditioning regimen is cyclophosphamide (CTX) with or without antithymocyte globulin (ATG), followed by short-term methotrexate (MTX) and cyclosporine A (CsA) to prevent graft-versus-host disease (GvHD).
In our pediatric oncology-hematology unit, a 5-year-old girl with SAA was treated with two BMT from the same HLA-identical sibling donor.
Severe CsA-induced adverse events (severe hypertension and PRES) after the first BMT led necessarily to CSA withdrawal.
Alternative immunosuppressive treatment for GvHD prevention as tacrolimus and mycophenolate were not tolerated by our patient because toxicity > grade II.
For this reason we decided to administrate sirolimus alone as GvHD prophylaxis and to prevent disease relapse after the rescue BMT.
Here we report the successful use of sirolimus alone for GvHD prophylaxis after the second transplant in a pediatric BMT setting for SAA.
American Psychological Association (APA)
Perruccio, Katia& Mastrodicasa, Elena& Arcioni, Francesco& Capolsini, Ilaria& Cerri, Carla& Gurdo, Grazia…[et al.]. 2015. Sirolimus-Based Immunosuppression as GvHD Prophylaxis after Bone Marrow Transplantation for Severe Aplastic Anaemia: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058593
Modern Language Association (MLA)
Perruccio, Katia…[et al.]. Sirolimus-Based Immunosuppression as GvHD Prophylaxis after Bone Marrow Transplantation for Severe Aplastic Anaemia: A Case Report and Review of the Literature. Case Reports in Hematology No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058593
American Medical Association (AMA)
Perruccio, Katia& Mastrodicasa, Elena& Arcioni, Francesco& Capolsini, Ilaria& Cerri, Carla& Gurdo, Grazia…[et al.]. Sirolimus-Based Immunosuppression as GvHD Prophylaxis after Bone Marrow Transplantation for Severe Aplastic Anaemia: A Case Report and Review of the Literature. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058593