Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage
Joint Authors
Menger, Richard P.
Dossani, Rimal H.
Thakur, Jai Deep
Farokhi, Frank
Morrow, Kevin
Guthikonda, Bharat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective and Importance.
To illustrate the development of spontaneous subdural hematoma secondary to aplastic anemia resulting from the administration of trimethoprim-sulfamethoxazole.
This is the first report of trimethoprim-sulfamethoxazole potentiating coagulopathy leading to any form of intracranial hematoma.
Clinical Presentation.
A 62-year-old female developed a bone marrow biopsy confirmed diagnosis of aplastic anemia secondary to administration of trimethoprim-sulfamethoxazole following a canine bite.
She then developed a course of waxing and waning mental status combined with headache and balance related falls.
CT imaging of the head illustrated a 3.7 cm × 6.6 mm left frontal subdural hematoma combined with a 7.0 mm × 1.7 cm left temporal epidural hematoma.
Conclusion.
Aplastic anemia is a rare complication of the administration of trimethoprim-sulfamethoxazole.
Thrombocytopenia, regardless of cause, is a risk factor for the development of spontaneous subdural hematoma.
Given the lack of a significant traumatic mechanism, this subset of subdural hematoma is more suitable to conservative management.
American Psychological Association (APA)
Menger, Richard P.& Dossani, Rimal H.& Thakur, Jai Deep& Farokhi, Frank& Morrow, Kevin& Guthikonda, Bharat. 2015. Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058601
Modern Language Association (MLA)
Menger, Richard P.…[et al.]. Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage. Case Reports in Hematology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058601
American Medical Association (AMA)
Menger, Richard P.& Dossani, Rimal H.& Thakur, Jai Deep& Farokhi, Frank& Morrow, Kevin& Guthikonda, Bharat. Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058601