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Langerhans Cell Histiocytosis in an Infant Mimicking a Lymphoma at Presentation
Joint Authors
Madasu, Anjan
Noor Rana, Asim
Banat, Saleh
Humad, Hani
Mustafa, Rashid
AlJassmi, Abdulrahman Mohd
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by proliferation and accumulation of clonal dendritic cells with varied clinical presentation and an unpredictable course.
We report a 5-month-old infant with LCH who presented with severe respiratory distress, a large mediastinal mass, significant generalized lymphadenopathy, and hepatosplenomegaly.
Lymphoma, especially T cell lymphoblastic lymphoma, can present with superior mediastinal syndrome needing urgent empirical therapy without biopsy.
However, lack of response prompted a biopsy which confirmed it to be a case of LCH and that leads to appropriate therapy and survival.
There have been reports of LCH presenting with isolated mediastinal mass or with generalized lymphadenopathy, but the combined presentation of generalized lymphadenopathy with large mediastinal mass, hepatosplenomegaly, and fever in an infant has rarely been reported.
Conclusion.
LCH should also be considered in the differential diagnosis of an infant presenting with generalized lymphadenopathy, mediastinal mass, hepatosplenomegaly, and fever.
American Psychological Association (APA)
Madasu, Anjan& Noor Rana, Asim& Banat, Saleh& Humad, Hani& Mustafa, Rashid& AlJassmi, Abdulrahman Mohd. 2015. Langerhans Cell Histiocytosis in an Infant Mimicking a Lymphoma at Presentation. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058624
Modern Language Association (MLA)
Madasu, Anjan…[et al.]. Langerhans Cell Histiocytosis in an Infant Mimicking a Lymphoma at Presentation. Case Reports in Hematology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058624
American Medical Association (AMA)
Madasu, Anjan& Noor Rana, Asim& Banat, Saleh& Humad, Hani& Mustafa, Rashid& AlJassmi, Abdulrahman Mohd. Langerhans Cell Histiocytosis in an Infant Mimicking a Lymphoma at Presentation. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058624