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Aggressive FLC Escape in a Patient with IgD Myeloma
Joint Authors
Farges, Cédric
Roussel, Murielle
Huynh, Anne
Blancher, Antoine
Puissant-Lubrano, Bénédicte
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Some patients who are stable or in remission from a myeloma secreting intact monoclonal immunoglobulin (+/− associated free light-chains (FLCs)) relapse with production of FLC.
This FLC escape is one of the illustrations of the intraclonal heterogeneity of multiple myeloma.
Results.
We report FLC escape in a patient with IgD myeloma characterized by a severe outcome.
We discuss parameters that negatively impacted prognosis in this patient, including bone lesions, biochemical parameters, and genomic abnormalities.
Conclusion.
This case illustrates the selective pressure exerted by therapeutic drugs and the variable sensitivity of subclones to these drugs; it also highlights the importance of FLC monitoring in treated MM patients.
American Psychological Association (APA)
Farges, Cédric& Roussel, Murielle& Huynh, Anne& Blancher, Antoine& Puissant-Lubrano, Bénédicte. 2015. Aggressive FLC Escape in a Patient with IgD Myeloma. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058628
Modern Language Association (MLA)
Farges, Cédric…[et al.]. Aggressive FLC Escape in a Patient with IgD Myeloma. Case Reports in Hematology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058628
American Medical Association (AMA)
Farges, Cédric& Roussel, Murielle& Huynh, Anne& Blancher, Antoine& Puissant-Lubrano, Bénédicte. Aggressive FLC Escape in a Patient with IgD Myeloma. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058628