Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature
Joint Authors
Yonal-Hindilerden, Ipek
Bulut-Dereli, Sanem
Yıldız, Eren
Dogan, Ibrahim Oner
Nalcaci, Meliha
Hindilerden, Fehmi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We describe an unusual case of hairy cell leukemia (HCL) in a 55-year-old male presenting with isolated skeletal disease as the initial manifestation without abnormal peripheral blood counts, bone marrow involvement, or splenomegaly.
To the best of our knowledge, there have been only two previous reports of a similar case.
The patient presented with pain in the right femur.
Anteroposterior radiographs of both femurs revealed mixed lytic-sclerotic lesions.
PET scan showed multiple metastatic lesions on axial skeleton, pelvis, and both femurs.
Histopathological examination of the bone biopsy revealed an infiltrate of HCL.
Localized radiation therapy to both proximal femurs and subsequently 4 weeks later, a 7-day course of 0.1 mg/kg/day cladribine provided complete remission with relief of symptoms and resolution of bone lesions.
We addressed the manifestations and management of HCL patients with skeletal involvement.
American Psychological Association (APA)
Yonal-Hindilerden, Ipek& Hindilerden, Fehmi& Bulut-Dereli, Sanem& Yıldız, Eren& Dogan, Ibrahim Oner& Nalcaci, Meliha. 2015. Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1058638
Modern Language Association (MLA)
Yonal-Hindilerden, Ipek…[et al.]. Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature. Case Reports in Hematology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1058638
American Medical Association (AMA)
Yonal-Hindilerden, Ipek& Hindilerden, Fehmi& Bulut-Dereli, Sanem& Yıldız, Eren& Dogan, Ibrahim Oner& Nalcaci, Meliha. Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1058638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058638