Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland
Joint Authors
Kraj, Maria
Kruk, Barbara
Endean, Kelly
Warzocha, Krzysztof
Budziszewska, Katarzyna
Dąbrowska, Monika
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report three cases of light chain escape (LCE) at a single institution in Poland, including an interesting case of biclonal monoclonal gammopathy of undetermined significance (MGUS) that satisfied the criteria for progression to light chain multiple myeloma (LCMM) with a rapid rise in serum free light chain (FLC) levels, following steroidal treatment for simultaneous temporal artery inflammation and polymyalgia rheumatica (PMR).
In the three cases discussed, progression of the disease by light chain escape was associated with rapid and severe renal impairment, highlighting the necessity for prompt detection of such free light chain-only producing clones in order to prevent the possible development of irreversible end-organ damage.
Interestingly, monitoring of these three patients by serum free light chain assay (sFLC) and retrospective heavy/light chain analysis (HLC) detected this clonal evolution prior to clinical relapse and suggests that these assays represent important additional tools for more accurate monitoring of multiple myeloma patients.
American Psychological Association (APA)
Kraj, Maria& Kruk, Barbara& Endean, Kelly& Warzocha, Krzysztof& Budziszewska, Katarzyna& Dąbrowska, Monika. 2015. Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058640
Modern Language Association (MLA)
Kraj, Maria…[et al.]. Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland. Case Reports in Hematology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1058640
American Medical Association (AMA)
Kraj, Maria& Kruk, Barbara& Endean, Kelly& Warzocha, Krzysztof& Budziszewska, Katarzyna& Dąbrowska, Monika. Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058640