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Nelarabine Associated Myotoxicity and Rhabdomyolysis
Joint Authors
Kasi, Pashtoon Murtaza
Haider, Mahnur
Rizvi, Syed Ahsan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Nelarabine (ara-G; Arranon; compound 506U78) is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).
The drug was granted accelerated approval in October 2005 by the US Food and Drug Administration (FDA) given the efficacy (induction of complete responses) noted in 2 single-arm trials (one in pediatric setting and one in adult patient population).
The main spectra of toxicities that have been reported in these clinical trials and subsequent studies are hematological and neurological.
Nelarabine induced rhabdomyolysis and increased creatinine phosphokinase (CK; CPK) levels apparently have been reported and this side effect has been added as an adverse reaction in the product monograph from the drug company during postmarketing surveillance.
However, the true extent and incidence of the myotoxicity from the drug are unclear.
In this paper we report a grade IV CK elevation and rhabdomyolysis in a patient with T-ALL treated with nelarabine.
Given the reported finding, we examined the literature further for myotoxicity, increased CK, and/or rhabdomyolysis associated with the use of the nelarabine and report our findings.
American Psychological Association (APA)
Haider, Mahnur& Rizvi, Syed Ahsan& Kasi, Pashtoon Murtaza. 2015. Nelarabine Associated Myotoxicity and Rhabdomyolysis. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058643
Modern Language Association (MLA)
Haider, Mahnur…[et al.]. Nelarabine Associated Myotoxicity and Rhabdomyolysis. Case Reports in Hematology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058643
American Medical Association (AMA)
Haider, Mahnur& Rizvi, Syed Ahsan& Kasi, Pashtoon Murtaza. Nelarabine Associated Myotoxicity and Rhabdomyolysis. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058643