Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia
Joint Authors
Kudo, Naoko
Saigo, Katsuyasu
Takagishi, Katsushige
Imashuku, Shinsaku
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report two cases of primary cold agglutinin disease (CAD) associated with megaloblastic anemia in Japanese elderly patients.
Case 1 was a 67-year-old male and Case 2 was a 55-year-old male.
Both patients were diagnosed with primary CAD, with continuously high cold agglutinin titers (1 : >8,192 and 1 : 16,834, resp.), monoclonal IgM-kappa light chains, and no underlying disease.
In addition, both patients had megaloblastic anemia due to vitamin B12 deficiency.
One patient received rituximab and both received vitamin 12 supplementation.
To date, no cooccurrence of primary CAD and megaloblastic anemia has been emphasized.
Thus, the association of these hematological diseases may be incidental; however, given that CAD is an autoimmune disease which may show antibodies against intrinsic factor and gastric parietal cells, this association was thought to be probably not a coincidence.
Clinicians should be aware of the possible simultaneous presence of autoimmune hemolytic/megaloblastic anemia in patients with primary CAD.
American Psychological Association (APA)
Imashuku, Shinsaku& Kudo, Naoko& Takagishi, Katsushige& Saigo, Katsuyasu. 2015. Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058649
Modern Language Association (MLA)
Imashuku, Shinsaku…[et al.]. Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia. Case Reports in Hematology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1058649
American Medical Association (AMA)
Imashuku, Shinsaku& Kudo, Naoko& Takagishi, Katsushige& Saigo, Katsuyasu. Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058649