Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy
Joint Authors
Zignego, Anna Linda
Gragnani, Laura
Urraro, Teresa
Piluso, Alessia
Fabbrizzi, Alessio
Monti, Monica
Boldrini, Barbara
Ranieri, Jessica
Fognani, Elisa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Mixed cryoglobulinemia (MC) is an autoimmune/B-cell lymphoproliferative disorder associated with Hepatitis C Virus (HCV) infection, manifesting as a systemic vasculitis.
In the last decade, antiviral treatment (AT) with pegylated interferon (Peg-IFN) plus ribavirin (RBV) was considered the first therapeutic option for HCV-MC.
In MC patients ineligible or not responsive to antivirals, the anti-CD20 monoclonal antibody rituximab (RTX) is effective.
A combined AT plus RTX was also suggested.
Since the introduction of direct acting antivirals (DAAs), few data were published about MC and no data about a combined schedule.
Here, we report a complete remission of MC after a sustained virological response following a combined RTX/Peg-IFN+RBV+DAA (boceprevir) treatment and review the literature about the combined RTX/AT.
American Psychological Association (APA)
Urraro, Teresa& Gragnani, Laura& Piluso, Alessia& Fabbrizzi, Alessio& Monti, Monica& Fognani, Elisa…[et al.]. 2015. Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy. Case Reports in Immunology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058680
Modern Language Association (MLA)
Urraro, Teresa…[et al.]. Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy. Case Reports in Immunology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1058680
American Medical Association (AMA)
Urraro, Teresa& Gragnani, Laura& Piluso, Alessia& Fabbrizzi, Alessio& Monti, Monica& Fognani, Elisa…[et al.]. Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based Antihepatitis C Virus Therapy. Case Reports in Immunology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1058680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058680