Lichen Planus Induced by Pegylated Interferon Alfa-2a Therapy in a Patient Monitored for Delta Hepatitis
Joint Authors
Arslan, Eyup
Baykara, Sule Nergiz
Uzun, Ozlem Ceren
Kaya, Sehmuz
Kaya, Safak
Baysal, Birol
Source
Case Reports in Infectious Diseases
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Interferons are used for treatment of chronic hepatitis B.
They can induce or exacerbate some skin disorders, such as lichen planus.
In this study, as we know, we presented the first case developing lichen planus while receiving interferon treatment due to delta hepatitis.
A 31-year-old male patient presented to our outpatient clinic with HBsAg positivity.
With his analyses, HBV DNA was negative, anti-delta total was positive, ALT was 72 U/L (upper limit 41 U/L), and platelet was 119 000/mm3.
He was therefore started on subcutaneous pegylated interferon alfa-2a therapy at 180 mcg/week for delta hepatitis.
At month 4 of therapy, the patient developed diffuse eroded lace-like lesions in oral mucosa, white plaques on lips, and itchy papular lesions in the hands and feet.
Lichen planus was considered by the dermatology clinic and topical treatment (mometasone furoate) was given.
The lesions persisted at month 5 of therapy and biopsy samples were obtained from oral mucosal lesions and interferon dose was reduced to 135 mcg/week.
Biopsy demonstrated nonkeratinized stratified squamous epithelium; epithelial acanthosis, spongiosis, and apoptotic bodies were observed in the epidermis and therefore lichen planus was considered.
At month 6 of therapy, lesions did not improve and even progressed and interferon treatment was therefore discontinued.
American Psychological Association (APA)
Kaya, Safak& Arslan, Eyup& Baysal, Birol& Baykara, Sule Nergiz& Uzun, Ozlem Ceren& Kaya, Sehmuz. 2015. Lichen Planus Induced by Pegylated Interferon Alfa-2a Therapy in a Patient Monitored for Delta Hepatitis. Case Reports in Infectious Diseases،Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058712
Modern Language Association (MLA)
Kaya, Safak…[et al.]. Lichen Planus Induced by Pegylated Interferon Alfa-2a Therapy in a Patient Monitored for Delta Hepatitis. Case Reports in Infectious Diseases No. 2015 (2015), pp.1-3.
https://search.emarefa.net/detail/BIM-1058712
American Medical Association (AMA)
Kaya, Safak& Arslan, Eyup& Baysal, Birol& Baykara, Sule Nergiz& Uzun, Ozlem Ceren& Kaya, Sehmuz. Lichen Planus Induced by Pegylated Interferon Alfa-2a Therapy in a Patient Monitored for Delta Hepatitis. Case Reports in Infectious Diseases. 2015. Vol. 2015, no. 2015, pp.1-3.
https://search.emarefa.net/detail/BIM-1058712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058712