Markedly Elevated Carbamazepine-10,11-epoxideCarbamazepine Ratio in a Fatal Carbamazepine Ingestion
Joint Authors
Russell, Jason L.
Spiller, Henry A.
Baker, Daniel D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Carbamazepine is a widely used anticonvulsant.
Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties.
While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent.
We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity.
American Psychological Association (APA)
Russell, Jason L.& Spiller, Henry A.& Baker, Daniel D.. 2015. Markedly Elevated Carbamazepine-10,11-epoxideCarbamazepine Ratio in a Fatal Carbamazepine Ingestion. Case Reports in Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058824
Modern Language Association (MLA)
Russell, Jason L.…[et al.]. Markedly Elevated Carbamazepine-10,11-epoxideCarbamazepine Ratio in a Fatal Carbamazepine Ingestion. Case Reports in Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058824
American Medical Association (AMA)
Russell, Jason L.& Spiller, Henry A.& Baker, Daniel D.. Markedly Elevated Carbamazepine-10,11-epoxideCarbamazepine Ratio in a Fatal Carbamazepine Ingestion. Case Reports in Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058824