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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab
Joint Authors
Broehm, Cory Julian
Garbrecht, Erika L.
Wood, Jeff
Bocklage, Therese
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence.
Sarcomatous transformation is rare and typically occurs with a history of recurrences and radiation treatment.
Denosumab, an inhibitor of the RANK ligand involved in bone resorption in GCT, is increasingly used in treatment of recurrent or unresectable giant cell tumor of bone.
We report two cases of sarcomatous transformation of GCT to osteosarcoma in patients receiving denosumab.
One was a 59-year-old male with a 12-year history of GCT and multiple recurrences taking denosumab for 2.5 years.
The second case was in a 56-year-old male with a seven-year history of GCT taking denosumab for six months.
Review of the literature shows one case report of malignant transformation of GCT in a patient being treated with denosumab.
As the use of denosumab for treatment of GCT will likely increase, larger, controlled studies are needed to ascertain whether denosumab may play a role in malignant transformation of giant cell tumor of bone.
American Psychological Association (APA)
Broehm, Cory Julian& Garbrecht, Erika L.& Wood, Jeff& Bocklage, Therese. 2015. Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab. Case Reports in Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058905
Modern Language Association (MLA)
Broehm, Cory Julian…[et al.]. Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab. Case Reports in Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1058905
American Medical Association (AMA)
Broehm, Cory Julian& Garbrecht, Erika L.& Wood, Jeff& Bocklage, Therese. Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab. Case Reports in Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1058905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058905